Rv0209

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv0209 CDS 249038 250123 + 1 086 361 FALSE

Rv0209 () is predicted to be co-regulated in modules bicluster_0536 with residual 0.53 and bicluster_0567 with residual 0.48.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.60 and 130.00 for bicluster_0536 and 200.00 and 6,500.00 for bicluster_0567 respectively.

These modules are enriched for following go terms: hydro-lyase activity.

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 4 of 4
ChipSeq TF Differential Expression Distance Expression pvalue Type
TetR/ACRR family transcriptional regulator
No -140 -0.13 0.983518 Primary.TSS
DNA-binding response regulator mtrA
No -103 0.07 0.912739 Primary.TSS
No -126 -0.36 0.221585 Primary.TSS
Transcriptional regulator, TetR family
No -103 0.25 0.449302 Primary.TSS
Motif 1 Motif 2 Residual
bicluster_0536
e.value: 
0.6
Motif Bicluster: 
e.value: 
130
Motif Bicluster: 
0.53
bicluster_0567
e.value: 
200
Motif Bicluster: 
e.value: 
6500
Motif Bicluster: 
0.48
Product (LegacyBRC) Product (RefSeq)
Putative uncharacterized protein
Operon # Operon
145 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics
Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15607350 NP_214723.1 Run
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.190000 0.87

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: