Rv0322 UDP-glucose dehydrogenase (EC 1.1.1.22)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv0322 udgA UDP-glucose dehydrogenase (EC 1.1.1.22) CDS 389260 390591 + 1 332 443 FALSE

Rv0322 (UDP-glucose dehydrogenase (EC 1.1.1.22)) is predicted to be co-regulated in modules bicluster_0071 with residual 0.59 and bicluster_0113 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.04 and 0.76 for bicluster_0071 and 3.20 and 170.00 for bicluster_0113 respectively.

These modules are enriched for following go terms: exodeoxyribonuclease activity, exodeoxyribonuclease activity, producing..., exonuclease activity, active with either..., deoxyribonuclease activity.

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0071
e.value: 
0.037
Motif Bicluster: 
e.value: 
0.76
Motif Bicluster: 
0.59
bicluster_0113
e.value: 
3.2
Motif Bicluster: 
e.value: 
170
Motif Bicluster: 
0.50
Product (LegacyBRC) Product (RefSeq)
PROBABLE UDP-GLUCOSE 6-DEHYDROGENASE UDGA [UDP-GLC DEHYDROGENASE] [UDP-GLCDH] [UDPGDH] UDP-glucose 6-dehydrogenase UdgA
Operon # Operon
223 Rv0322
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Pentose and glucuronate interconversions

8
Total items in this category:  

KEGG

Ascorbate and aldarate metabolism

5
Total items in this category:  

KEGG

Starch and sucrose metabolism

20
Total items in this category:  

KEGG

Amino sugar and nucleotide sugar metabolism

28
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  

KEGG

Biosynthesis of secondary metabolites

326
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15607463 NP_214836.1 Run
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.330000 0.95

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.