Rv0634A

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv0634A CDS 731113 731364 + 252 83 FALSE

Rv0634A () is predicted to be co-regulated in modules with residual and with residual .

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , and for and and for respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

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Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 10 of 14
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, TetR family
No -134 -0.02 0.981941 Antisense.TSS
Two component transcriptional regulatory protein DevR
No -51 -0.47 0.00645072 Internal.TSS
Possible oxidoreductase subunit
No -109 0.27 0.485097 Internal.TSS
No -125 0.08 0.937363 Internal.TSS
Possible oxidoreductase subunit
No -135 0.27 0.485097 Antisense.TSS
No -86 0.08 0.937363 CDS
Two component transcriptional regulatory protein DevR
No 22 -0.47 0.00645072 Internal.TSS
Transcriptional regulator, TetR family
No -69 -0.02 0.981941 CDS
Two component transcriptional regulatory protein DevR
No 61 -0.47 0.00645072 CDS
Transcriptional regulator, TetR family
No -108 -0.02 0.981941 Internal.TSS
Product (LegacyBRC) Product (RefSeq)
Putative uncharacterized protein
Operon # Operon
426
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics
Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
57116763 YP_177629.1 Run
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.550000 1.66

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: