Rv0650 Sugar kinase

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv0650 Sugar kinase CDS 747037 747945 + 909 302 FALSE

Rv0650 (Sugar kinase) is predicted to be co-regulated in modules bicluster_0311 with residual 0.51 and bicluster_0371 with residual 0.54.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.00 for bicluster_0311 and 0.10 and 3.90 for bicluster_0371 respectively.

These modules are enriched for following go terms: anion transport.

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN
No 63 0.07 0.925545 CDS
Motif 1 Motif 2 Residual
bicluster_0311
e.value: 
0.0000094
Motif Bicluster: 
e.value: 
0.00031
Motif Bicluster: 
0.51
bicluster_0371
e.value: 
0.1
Motif Bicluster: 
e.value: 
3.9
Motif Bicluster: 
0.54
Product (LegacyBRC) Product (RefSeq)
POSSIBLE SUGAR KINASE sugar kinase
Operon # Operon
438 Rv0648 - Rv0649 - Rv0650
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Glycolysis / Gluconeogenesis

35
Total items in this category:  

KEGG

Galactose metabolism

14
Total items in this category:  

KEGG

Starch and sucrose metabolism

20
Total items in this category:  

KEGG

Amino sugar and nucleotide sugar metabolism

28
Total items in this category:  

KEGG

Streptomycin biosynthesis

12
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  

KEGG

Biosynthesis of secondary metabolites

326
Total items in this category:  

KEGG

Microbial metabolism in diverse environments

296
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15607790 NP_215164.1 Run
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.640000 0.96

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.