Rv0729 Putative xylulose kinase (EC 2.7.1.17)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv0729 xylB Putative xylulose kinase (EC 2.7.1.17) CDS 821507 822853 + 1 347 448 FALSE

Rv0729 (Putative xylulose kinase (EC 2.7.1.17)) is predicted to be co-regulated in modules bicluster_0345 with residual 0.48 and bicluster_0591 with residual 0.62.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 3,300.00 and 4,600.00 for bicluster_0345 and 56.00 and 610.00 for bicluster_0591 respectively.

These modules are enriched for following go terms: .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 2 of 2
ChipSeq TF Differential Expression Distance Expression pvalue Type
Beta-carotene ketolase (EC 1.14.-.-)
No -15 0.23 0.999473 CDS
Transcriptional regulator, PadR family
No 44 -0.37 0.962221 CDS
Motif 1 Motif 2 Residual
bicluster_0345
e.value: 
3300
Motif Bicluster: 
e.value: 
4600
Motif Bicluster: 
0.48
bicluster_0591
e.value: 
56
Motif Bicluster: 
e.value: 
610
Motif Bicluster: 
0.62
Product (LegacyBRC) Product (RefSeq)
POSSIBLE D-XYLULOSE KINASE XYLB [XYLULOKINASE] [XYLULOSE KINASE] D-xylulose kinase XylB
Operon # Operon
481 Rv0729 - Rv0730
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Xylulokinase Pentose and glucuronate interconversions
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Pentose and glucuronate interconversions

8
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15607869 NP_215243.1 Run
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.510000 0.96

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.