Rv0746 PE-PGRS virulence associated protein

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv0746 PE_PGRS9 PE-PGRS virulence associated protein CDS 835701 838052 + 2 352 783 FALSE

Rv0746 (PE-PGRS virulence associated protein) is predicted to be co-regulated in modules bicluster_0336 with residual 0.51 and bicluster_0461 with residual 0.55.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.44 for bicluster_0336 and 23.00 and 620.00 for bicluster_0461 respectively.

These modules are enriched for following go terms: .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, MarR family
Repressed -55 -1.82 0.000000634 CDS
Motif 1 Motif 2 Residual
bicluster_0336
e.value: 
0.00015
Motif Bicluster: 
e.value: 
0.44
Motif Bicluster: 
0.51
bicluster_0461
e.value: 
23
Motif Bicluster: 
e.value: 
620
Motif Bicluster: 
0.55
Product (LegacyBRC) Product (RefSeq)
PE-PGRS FAMILY PROTEIN PE-PGRS family protein
Operon # Operon
493 Rv0745 - Rv0746
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
57116773 YP_177750.1 Run
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.070000 1.08

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.