Rv0768 Aldehyde dehydrogenase (EC 1.2.1.3)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv0768 aldA Aldehyde dehydrogenase (EC 1.2.1.3) CDS 860912 862381 + 1 470 489 FALSE

Rv0768 (Aldehyde dehydrogenase (EC 1.2.1.3)) is predicted to be co-regulated in modules bicluster_0418 with residual 0.49 and bicluster_0548 with residual 0.54.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 7.60 for bicluster_0418 and 0.00 and 0.26 for bicluster_0548 respectively.

These modules are enriched for following go terms: .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 08:59
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-13624 MT0792 1020
Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 2 of 2
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, ArsR family
Repressed -123 -0.85 0.00691037 CDS
Possible oxidoreductase subunit
Induced -58 1.18 0.00000474 CDS
Motif 1 Motif 2 Residual
bicluster_0418
e.value: 
0.00032
Motif Bicluster: 
e.value: 
7.6
Motif Bicluster: 
0.49
bicluster_0548
e.value: 
0.000078
Motif Bicluster: 
e.value: 
0.26
Motif Bicluster: 
0.54
Product (LegacyBRC) Product (RefSeq)
PROBABLE ALDEHYDE DEHYDROGENASE NAD DEPENDENT ALDA [ALDEHYDE DEHYDROGENASE [NAD+]] aldehyde dehydrogenase NAD dependent AldA
Operon # Operon
508 Rv0768 - Rv0769
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Glycolysis / Gluconeogenesis

35
Total items in this category:  

KEGG

Pentose and glucuronate interconversions

8
Total items in this category:  

KEGG

Ascorbate and aldarate metabolism

5
Total items in this category:  

KEGG

Fatty acid metabolism

51
Total items in this category:  

KEGG

Valine, leucine and isoleucine degradation

60
Total items in this category:  

KEGG

Lysine degradation

46
Total items in this category:  

KEGG

Arginine and proline metabolism

38
Total items in this category:  

KEGG

Histidine metabolism

40
Total items in this category:  

KEGG

Tryptophan metabolism

47
Total items in this category:  

KEGG

beta-Alanine metabolism

37
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15607908 NP_215282.1 Run
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.020000 1.05

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.