Rv0894 Disease resistance domain-containing protein

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv0894 Disease resistance domain-containing protein CDS 996524 997705 + 1 182 393 TRUE

Rv0894 (Disease resistance domain-containing protein) is predicted to be co-regulated in modules bicluster_0260 with residual 0.50 and bicluster_0452 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.86 for bicluster_0260 and 0.00 and 0.00 for bicluster_0452 respectively.

These modules are enriched for following go terms: aspartate-tRNA ligase activity.

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

BASS Score New Primary UTR Primary TSS Re-Annotated Start Tuberculist Annotated Start
-0.578 149 996447 996596 996524
Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
Type VII secretion integral membrane protein EccD
No -64 0.05 0.956846 Primary.TSS
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0260
e.value: 
0.00000000083
Motif Bicluster: 
e.value: 
0.86
Motif Bicluster: 
0.50
bicluster_0452
e.value: 
0.000000058
Motif Bicluster: 
e.value: 
0.00000084
Motif Bicluster: 
0.53
Product (LegacyBRC) Product (RefSeq)
Uncharacterized protein Rv0894_MT0918 LuxR family transcriptional regulator
Operon # Operon
599 Rv0894
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608034 NP_215409.1 Run
GO:0005829

cytosol

cytosol

Details: 
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO Category: 
cellular_component
371
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
BioProject Accession GEO Series References Repository Sample Method Sample Type
PRJNA254351 GSM1426587 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426588 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426589 GSE59086 25232098 GEO Tiling Array RNA
Experiment UCSC Genome Browser
Rv0894_B259 UCSC Browser Tracks
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.610000 1.63

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D0U 27 0 0.00 2.78 U
D3I 3 3 3.83 1.90 I
D3U 3 3 3.83 1.88 U
D5I 9 5 6.00 I
D5U 17 5 6.00 U
D7I 18 7 8.14 3.19 I
D7U 19 7 8.14 4.04 U
D14I 4 14 15.63 2.24 I
D14U 4 14 15.63 2.75 U
D17I 3 17 19.15 I
D17U 3 17 19.15 U
D21I 4 21 23.23 I
D21U 4 21 23.23 1.39 U
D24I 3 24 26.60 I
D24U 3 24 26.60 2.22 U
D28I 4 28 30.61 I
D28U 4 28 30.61 U