Rv0935 Phosphate transport system permease protein PstC (TC 3.A.1.7.1)

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv0935 pstC1 Phosphate transport system permease protein PstC (TC 3.A.1.7.1) CDS 1043299 1044315 + 1 017 338 FALSE

Rv0935 (Phosphate transport system permease protein PstC (TC 3.A.1.7.1)) is predicted to be co-regulated in modules bicluster_0269 with residual 0.48 and bicluster_0480 with residual 0.52.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 150.00 and 1,600.00 for bicluster_0269 and 0.30 and 53.00 for bicluster_0480 respectively.

These modules are enriched for following go terms: tryptophan metabolic process, indolalkylamine metabolic process, indole-containing compound metabolic pro..., cellular biogenic amine metabolic proces..., active transmembrane transporter activit..., transporter activity .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Rv0935 phosphate ABC transporter transmembrane protein
Operon # Operon
623 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


ABC transporters

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
57116802 YP_177771.1 Run

transporter activity

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
GO Category: 
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Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
GO Category: 
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The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
GO Category: 
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No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.540000 1.40

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: