Rv0993 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv0993 galU UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) CDS 1109272 1110192 + 921 306 FALSE

Rv0993 (UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9)) is predicted to be co-regulated in modules bicluster_0033 with residual 0.56 and bicluster_0551 with residual 0.63.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.00 for bicluster_0033 and 390.00 and 4,300.00 for bicluster_0551 respectively.

These modules are enriched for following go terms: .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No -79 -0.3 0.374254 Primary.TSS
Motif 1 Motif 2 Residual
bicluster_0033
e.value: 
0.00027
Motif Bicluster: 
e.value: 
0.00094
Motif Bicluster: 
0.56
bicluster_0551
e.value: 
390
Motif Bicluster: 
e.value: 
4300
Motif Bicluster: 
0.63
Product (LegacyBRC) Product (RefSeq)
PROBABLE UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE GALU [UDP-GLUCOSE PYROPHOSPHORYLASE] [UDPGP] [ALPHA-D-GLUCOSYL-1-PHOSPHATE URIDYLYLTRANSFERASE] [URIDINE DIPHOSPHOGLUCOSE PYROPHOSPHORYLASE] UTP--glucose-1-phosphate uridylyltransferase GalU
Operon # Operon
663 Rv0993
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Pentose and glucuronate interconversions

8
Total items in this category:  

KEGG

Galactose metabolism

14
Total items in this category:  

KEGG

Starch and sucrose metabolism

20
Total items in this category:  

KEGG

Amino sugar and nucleotide sugar metabolism

28
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  

KEGG

Biosynthesis of secondary metabolites

326
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608133 NP_215508.1 Run
GO:0003983

UTP:glucose-1-phosphate uridylyltransferase activity

UTP:glucose-1-phosphate uridylyltransferase activity

Details: 
Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose.
GO Category: 
molecular_function
1
Total items in this category:  
GO:0003983

UTP:glucose-1-phosphate uridylyltransferase activity

UTP:glucose-1-phosphate uridylyltransferase activity

Details: 
Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose.
GO Category: 
molecular_function
1
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.