Rv1158c Conserved alanine and proline rich protein

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv1158c Conserved alanine and proline rich protein FALSE

Rv1158c (Conserved alanine and proline rich protein) is predicted to be co-regulated in modules bicluster_0288 with residual 0.46 and bicluster_0393 with residual 0.48.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.23 and 2,800.00 for bicluster_0288 and 0.00 and 14.00 for bicluster_0393 respectively.

These modules are enriched for following go terms: cellular component biogenesis, cellular component organization or bioge..., carbohydrate binding, acid-amino acid ligase activity .

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 11:09
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-18598 MT1194 2657
Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 9 of 9
ChipSeq TF Differential Expression Distance Expression pvalue Type
DNA-binding response regulator TrcR
Repressed 46 -1.17 0.000296473 Primary.TSS
Transcriptional regulator, TetR family
No -29 -0.16 0.821224 Primary.TSS
transcriptional regulator, ArsR family
Repressed 52 -1.73 1.74e-19 Primary.TSS
Transcriptional regulatory protein
No 59 -0.57 0.0503775 Primary.TSS
Beta-carotene ketolase (EC 1.14.-.-)
No 30 0.02 0.999473 Primary.TSS
DNA-binding response regulator mtrA
No 56 0.32 0.70583 Primary.TSS
Transcriptional regulator kstR (Rv3574), TetR family
No 42 -0.12 0.761674 Primary.TSS
Transcriptional regulator, TetR family
No 3 -0.18 0.729963 Primary.TSS
Transcriptional regulator, TetR family
No 50 -0.38 0.37043 Primary.TSS
Motif 1 Motif 2 Residual
bicluster_0288
e.value: 
0.23
Motif Bicluster: 
e.value: 
2800
Motif Bicluster: 
0.46
bicluster_0393
e.value: 
0.00043
Motif Bicluster: 
e.value: 
14
Motif Bicluster: 
0.48
Product (LegacyBRC) Product (RefSeq)
Operon # Operon
784 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608298 NP_215674.1 Run
GO:0005576

extracellular region

extracellular region

Details: 
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO Category: 
cellular_component
272
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.560000 2.96

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: