Rv1167c Transcriptional regulator, TetR family

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv1167c Transcriptional regulator, TetR family CDS 1298087 1298692 - 606 201 TRUE

Rv1167c (Transcriptional regulator, TetR family) is predicted to be co-regulated in modules bicluster_0159 with residual 0.51 and bicluster_0412 with residual 0.47.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 2.90 and 6,600.00 for bicluster_0159 and 0.29 and 2.60 for bicluster_0412 respectively.

These modules are enriched for following go terms: .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 7 of 7
Gene Target Differential Expression Distance Expression pvalue Type
Arylsulfatase (EC 3.1.6.1)
No -3 -0.35 0.665394 Primary.TSS
N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB
No -101 0.31 0.610148 CDS
No -84 0.32 0.766017 Primary.TSS
FIG055075: Possibly a cell division protein, antigen 84 in Mycobacteria
No 66 0.11 0.787935 Primary.TSS
No -105 0.24 0.784747 CDS
DNA topoisomerase I (EC 5.99.1.2)
No -24 -0.44 0.139401 Primary.TSS
Induced -68 0.99 0.000985722 Primary.TSS
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0159
e.value: 
2.9
Motif Bicluster: 
e.value: 
6600
Motif Bicluster: 
0.51
bicluster_0412
e.value: 
0.29
Motif Bicluster: 
e.value: 
2.6
Motif Bicluster: 
0.47
Product (LegacyBRC) Product (RefSeq)
PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN transcriptional regulatory protein
Operon # Operon
791 Rv1167c
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608307 NP_215683.1 Run
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
BioProject Accession GEO Series References Repository Sample Method Sample Type
PRJNA254351 GSM1426625 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426626 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426627 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426625 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426626 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426627 GSE59086 25232098 GEO Tiling Array RNA
Experiment UCSC Genome Browser
Rv1167c_B333 UCSC Browser Tracks
Rv1167c_B346 UCSC Browser Tracks
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.220000 0.40

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D0U 27 0 0.00 9.66 U
D3I 3 3 3.83 7.94 I
D3U 3 3 3.83 8.22 U
D5I 9 5 6.00 14.00 I
D5U 17 5 6.00 13.62 U
D7I 18 7 8.14 9.74 I
D7U 19 7 8.14 9.40 U
D14I 4 14 15.63 7.67 I
D14U 4 14 15.63 7.29 U
D17I 3 17 19.15 7.47 I
D17U 3 17 19.15 7.14 U
D21I 4 21 23.23 7.52 I
D21U 4 21 23.23 7.08 U
D24I 3 24 26.60 7.28 I
D24U 3 24 26.60 6.84 U
D28I 4 28 30.61 7.18 I
D28U 4 28 30.61 7.11 U