Rv1167c Transcriptional regulator, TetR family

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv1167c Transcriptional regulator, TetR family CDS 1298087 1298692 - 606 201 TRUE

Rv1167c (Transcriptional regulator, TetR family) is predicted to be co-regulated in modules bicluster_0159 with residual 0.51 and bicluster_0412 with residual 0.47.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 2.90 and 6,600.00 for bicluster_0159 and 0.29 and 2.60 for bicluster_0412 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 7 of 7
Gene Target Differential Expression Distance Expression pvalue Type
Arylsulfatase (EC 3.1.6.1)
No -3 -0.35 0.665394 Primary.TSS
N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB
No -101 0.31 0.610148 CDS
No -84 0.32 0.766017 Primary.TSS
FIG055075: Possibly a cell division protein, antigen 84 in Mycobacteria
No 66 0.11 0.787935 Primary.TSS
No -105 0.24 0.784747 CDS
DNA topoisomerase I (EC 5.99.1.2)
No -24 -0.44 0.139401 Primary.TSS
Induced -68 0.99 0.000985722 Primary.TSS
Product (LegacyBRC) Product (RefSeq)
PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN transcriptional regulatory protein
Operon # Operon
791
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608307 NP_215683.1 Run
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
BioProject Accession GEO Series References Repository Sample Method Sample Type
PRJNA254351 GSM1426625 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426626 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426627 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426625 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426626 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426627 GSE59086 25232098 GEO Tiling Array RNA
Experiment UCSC Genome Browser
Rv1167c_B333 UCSC Browser Tracks
Rv1167c_B346 UCSC Browser Tracks
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.220000 0.40

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated: 0.275308
p-value INH: 0.988908
Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D3I 3 3 3.83 7.94 I
D5I 9 5 6.00 14.00 I
D7I 18 7 8.14 9.74 I
D14I 4 14 15.63 7.67 I
D17I 3 17 19.15 7.47 I
D21I 4 21 23.23 7.52 I
D24I 3 24 26.60 7.28 I
D28I 4 28 30.61 7.18 I
D0U 27 0 0.00 9.66 U
D3U 3 3 3.83 8.22 U
D5U 17 5 6.00 13.62 U
D7U 19 7 8.14 9.40 U
D14U 4 14 15.63 7.29 U
D17U 3 17 19.15 7.14 U
D21U 4 21 23.23 7.08 U
D24U 3 24 26.60 6.84 U
D28U 4 28 30.61 7.11 U