Rv1212c Predicted glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21), Actinobacterial type

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1212c glgA Predicted glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21), Actinobacterial type CDS 1354498 1355661 - 1 164 387 FALSE

Rv1212c (Predicted glycogen synthase, ADP-glucose transglucosylase (EC 2.4.1.21), Actinobacterial type) is predicted to be co-regulated in modules bicluster_0214 with residual 0.47 and bicluster_0221 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 56.00 and 3.00 for bicluster_0214 and 15.00 and 780.00 for bicluster_0221 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 11:09
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-17952 MT1250 993
Product (LegacyBRC) Product (RefSeq)
PUTATIVE GLYCOSYL TRANSFERASE putative glycosyl transferase
Operon # Operon
826
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Starch synthase Starch and sucrose metabolism
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608352 NP_215728.1 Run
GO:0009250

glucan biosynthetic process

glucan biosynthetic process

Details: 
The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.
GO Category: 
biological_process
3
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.230000 1.02

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: