Rv1230c POSSIBLE MEMBRANE PROTEIN

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv1230c POSSIBLE MEMBRANE PROTEIN CDS 1372962 1374197 - 1 236 411 FALSE

Rv1230c (POSSIBLE MEMBRANE PROTEIN) is predicted to be co-regulated in modules bicluster_0413 with residual 0.50 and bicluster_0438 with residual 0.51.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.12 and 0.15 for bicluster_0413 and 2.50 and 3,200.00 for bicluster_0438 respectively.

These modules are enriched for following go terms: porphyrin-containing compound metabolic ..., porphyrin-containing compound biosynthet..., cofactor biosynthetic process, sulfur amino acid biosynthetic process, sulfur amino acid metabolic process, cofactor metabolic process.

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 4 of 4
ChipSeq TF Differential Expression Distance Expression pvalue Type
Repressed -11 -0.72 0.00118394 Primary.TSS
transcriptional regulator, ArsR family
Repressed -16 -0.61 0.0000337 Primary.TSS
DNA-binding response regulator TrcR
No -34 -0.57 0.0569504 Primary.TSS
Transcriptional regulatory protein
Repressed -32 -1.83 3.34e-19 Primary.TSS
Motif 1 Motif 2 Residual
bicluster_0413
e.value: 
0.12
Motif Bicluster: 
e.value: 
0.15
Motif Bicluster: 
0.50
bicluster_0438
e.value: 
2.5
Motif Bicluster: 
e.value: 
3200
Motif Bicluster: 
0.51
Product (LegacyBRC) Product (RefSeq)
POSSIBLE MEMBRANE PROTEIN
Operon # Operon
837 Rv1229c - Rv1230c
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608370 NP_215746.1 Run
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.830000 1.22

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.