Rv1512 GDP-fucose synthetase

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1512 epiA GDP-fucose synthetase CDS 1704093 1705061 + 969 322 FALSE

Rv1512 (GDP-fucose synthetase) is predicted to be co-regulated in modules bicluster_0025 with residual 0.54 and bicluster_0153 with residual 0.56.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.31 and 8.20 for bicluster_0025 and 0.01 and 20.00 for bicluster_0153 respectively.

These modules are enriched for following go terms: nucleotide-sugar metabolic process nucleotide metabolic process.

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Probable nucleotide-sugar epimerase epiA nucleotide-sugar epimerase epiA
Operon # Operon
1007 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Fructose and mannose metabolism

Total items in this category:  


Amino sugar and nucleotide sugar metabolism

Total items in this category:  


Metabolic pathways

Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608650 NP_216028.1 Run
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: