Rv1604 Histidinol-phosphatase [alternative form] (EC 3.1.3.15)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1604 impA Histidinol-phosphatase [alternative form] (EC 3.1.3.15) CDS 1804039 1804851 + 813 270 FALSE

Rv1604 (Histidinol-phosphatase [alternative form] (EC 3.1.3.15)) is predicted to be co-regulated in modules bicluster_0135 with residual 0.54 and bicluster_0399 with residual 0.58.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 3.10 and 2,200.00 for bicluster_0135 and 570.00 and 670.00 for bicluster_0399 respectively.

These modules are enriched for following go terms: small molecule biosynthetic process, single-organism biosynthetic process, aromatic compound biosynthetic process, heterocycle biosynthetic process, organic cyclic compound biosynthetic pro... branched-chain amino acid metabolic proc....

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0135
e.value: 
3.1
Motif Bicluster: 
e.value: 
2200
Motif Bicluster: 
0.54
bicluster_0399
e.value: 
570
Motif Bicluster: 
e.value: 
670
Motif Bicluster: 
0.58
Product (LegacyBRC) Product (RefSeq)
PROBABLE INOSITOL-MONOPHOSPHATASE IMPA [IMP] inositol-monophosphatase
Operon # Operon
1054 Rv1599 - Rv1600 - Rv1601 - Rv1602 - Rv1603 - Rv1604 - Rv1605 - Rv1606
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Histidinol-phosphatase Histidine metabolism
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Streptomycin biosynthesis

12
Total items in this category:  

KEGG

Inositol phosphate metabolism

9
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  

KEGG

Biosynthesis of secondary metabolites

326
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608742 NP_216120.1 Run
GO:0004401

histidinol-phosphatase activity

histidinol-phosphatase activity

Details: 
Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate.
GO Category: 
molecular_function
2
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.230000 2.23

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.