Rv1622c Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1622c cydB Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-) CDS 1823360 1824400 - 1 041 346 FALSE

Rv1622c (Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-)) is predicted to be co-regulated in modules bicluster_0017 with residual 0.60 and bicluster_0260 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.25 and 10.00 for bicluster_0017 and 0.00 and 0.86 for bicluster_0260 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Probable integral membrane cytochrome D ubiquinol oxidase [Subunit II] cydB [Cytochrome BD-I oxidase subunit II] integral membrane cytochrome D ubiquinol oxidase (subunit II) cydB (cytochrome bd-I oxidase subunit II)
Operon # Operon
1064 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

With oxygen as acceptor. Betalain biosynthesis
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Oxidative phosphorylation

47
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608760 NP_216138.1 Run
GO:0006118

electron transport

electron transport

Details: 
OBSOLETE. The transport of electrons from an electron donor to an electron acceptor.
GO Category: 
biological_process
11
Total items in this category:  
GO:0016020

membrane

membrane

Details: 
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
GO Category: 
cellular_component
33
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.750000 3.85

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: