Rv1675c \transcriptional regulator, Crp/Fnr family\\\""

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1675c cmr \transcriptional regulator, Crp/Fnr family\\\"" CDS 1900241 1900975 - 735 244 TRUE

Rv1675c (\transcriptional regulator, Crp/Fnr family\\\"") is predicted to be co-regulated in modules bicluster_0062 with residual 0.51 and bicluster_0348 with residual 0.54.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 18.00 and 490.00 for bicluster_0062 and 0.03 and 16,000.00 for bicluster_0348 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 4 of 4
Gene Target Differential Expression Distance Expression pvalue Type
No -71 0.09 0.998661 Antisense.TSS
No -51 0.01 0.998661 Internal.TSS
No -51 -0.35 0.998661 Primary.TSS
No -47 -0.06 0.998661 Internal.TSS
Product (LegacyBRC) Product (RefSeq)
Operon # Operon
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608813 NP_216191.1 Run

DNA binding

DNA binding

Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).
GO Category: 
Total items in this category:  

regulation of transcription, DNA-dependent

regulation of transcription, DNA-dependent

Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription.
GO Category: 
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
BioProject Accession GEO Series References Repository Sample Method Sample Type
PRJNA254351 GSM1426708 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426709 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426710 GSE59086 25232098 GEO Tiling Array RNA
Experiment UCSC Genome Browser
Rv1675c_B457 UCSC Browser Tracks
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.580000 32.51

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated: 0.00145984
p-value INH: 0.725941
Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D0U 27 0 0.00 12.15 U
D3I 3 3 3.83 12.58 I
D3U 3 3 3.83 12.04 U
D5I 9 5 6.00 12.58 I
D5U 17 5 6.00 12.65 U
D7I 18 7 8.14 11.98 I
D7U 19 7 8.14 12.13 U
D14I 4 14 15.63 10.08 I
D14U 4 14 15.63 11.11 U
D17I 3 17 19.15 8.59 I
D17U 3 17 19.15 10.70 U
D21I 4 21 23.23 8.45 I
D21U 4 21 23.23 10.94 U
D24I 3 24 26.60 6.80 I
D24U 3 24 26.60 10.52 U
D28I 4 28 30.61 6.63 I
D28U 4 28 30.61 10.74 U