Rv1689 Tyrosyl-tRNA synthetase (EC 6.1.1.1)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1689 tyrS Tyrosyl-tRNA synthetase (EC 6.1.1.1) CDS 1913602 1914876 + 1 275 424 FALSE

Rv1689 (Tyrosyl-tRNA synthetase (EC 6.1.1.1)) is predicted to be co-regulated in modules bicluster_0154 with residual 0.56 and bicluster_0187 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 6.50 and 19,000.00 for bicluster_0154 and 0.01 and 0.16 for bicluster_0187 respectively.

These modules are enriched for following go terms: nitrate reductase complex, nitrate reductase activity, oxidoreductase activity, acting on other... organophosphate biosynthetic process, phospholipid metabolic process, phospholipid biosynthetic process.

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0154
e.value: 
6.5
Motif Bicluster: 
e.value: 
19000
Motif Bicluster: 
0.56
bicluster_0187
e.value: 
0.0061
Motif Bicluster: 
e.value: 
0.16
Motif Bicluster: 
0.50
Product (LegacyBRC) Product (RefSeq)
Tyrosyl-tRNA synthetase tyrosyl-tRNA synthetase
Operon # Operon
1103 Rv1688 - Rv1689
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Tyrosine--tRNA ligase Aminoacyl-tRNA biosynthesis
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Aminoacyl-tRNA biosynthesis

69
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608827 NP_216205.1 Run
GO:0004831

tyrosine-tRNA ligase activity

tyrosine-tRNA ligase activity

Details: 
Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).
GO Category: 
molecular_function
1
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.