Rv1700 ADP-ribose pyrophosphatase (EC 3.6.1.13)

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv1700 ADP-ribose pyrophosphatase (EC 3.6.1.13) CDS 1925582 1926205 + 624 207 FALSE

Rv1700 (ADP-ribose pyrophosphatase (EC 3.6.1.13)) is predicted to be co-regulated in modules bicluster_0280 with residual 0.58 and bicluster_0433 with residual 0.52.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 5.00 and 20.00 for bicluster_0280 and 0.00 and 0.00 for bicluster_0433 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Putative uncharacterized protein
Operon # Operon
1106 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

ADP-ribose diphosphatase Purine metabolism
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Purine metabolism

65
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608838 NP_216216.1 Run
GO:0047631

ADP-ribose diphosphatase activity

ADP-ribose diphosphatase activity

Details: 
Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.
GO Category: 
molecular_function
1
Total items in this category:  
GO:0030145

manganese ion binding

manganese ion binding

Details: 
Interacting selectively and non-covalently with manganese (Mn) ions.
GO Category: 
molecular_function
31
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.990000 1.39

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: