Rv1707 Sulfate permease

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv1707 Sulfate permease CDS 1934882 1936342 + 1 461 486 FALSE

Rv1707 (Sulfate permease) is predicted to be co-regulated in modules bicluster_0149 with residual 0.40 and bicluster_0573 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 5,200.00 and 6,300.00 for bicluster_0149 and 49.00 and 180.00 for bicluster_0573 respectively.

These modules are enriched for following go terms: cellular component biogenesis.

This gene is found to be for growth on cholesterol.

Mutant available?:

BASS Score New Primary UTR Primary TSS Re-Annotated Start Tuberculist Annotated Start
-0.661 119 1934799 1934918 1934882
Product (LegacyBRC) Product (RefSeq)
PROBABLE CONSERVED TRANSMEMBRANE PROTEIN transmembrane protein
Operon # Operon
1113 - - - - - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608845 NP_216223.1 Run
GO:0015137

citrate transmembrane transporter activity

citrate transmembrane transporter activity

Details: 
Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other.
GO Category: 
molecular_function
1
Total items in this category:  
GO:0008324

cation transmembrane transporter activity

cation transmembrane transporter activity

Details: 
Catalysis of the transfer of cation from one side of the membrane to the other.
GO Category: 
molecular_function
6
Total items in this category:  
GO:0006810

transport

transport

Details: 
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
GO Category: 
biological_process
28
Total items in this category:  
GO:0015746

citrate transport

citrate transport

Details: 
The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO Category: 
biological_process
1
Total items in this category:  
GO:0016021

integral to membrane

integral to membrane

Details: 
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
GO Category: 
cellular_component
6
Total items in this category:  
GO:0006813

potassium ion transport

potassium ion transport

Details: 
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO Category: 
biological_process
5
Total items in this category:  
GO:0005215

transporter activity

transporter activity

Details: 
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
GO Category: 
molecular_function
27
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.000000 0.53

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: