Rv1853 Urease accessory protein UreD

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1853 ureD Urease accessory protein UreD CDS 2101022 2101648 + 627 208 FALSE

Rv1853 (Urease accessory protein UreD) is predicted to be co-regulated in modules bicluster_0248 with residual 0.48 and bicluster_0506 with residual 0.55.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 4.60 and 3,700.00 for bicluster_0248 and 0.02 and 2.50 for bicluster_0506 respectively.

These modules are enriched for following go terms: nitrogen cycle metabolic process .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Probable urease accessory protein ureD urease accessory protein ureD
Operon # Operon
1213 - - - - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608990 NP_216369.1 Run

nickel cation binding

nickel cation binding

Interacting selectively and non-covalently with nickel (Ni) cations.
GO Category: 
Total items in this category:  

nitrogen compound metabolic process

nitrogen compound metabolic process

The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
GO Category: 
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.870000 1.92

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: