Rv1858 Molybdenum transport system permease protein ModB (TC 3.A.1.8.1)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1858 modB Molybdenum transport system permease protein ModB (TC 3.A.1.8.1) CDS 2105773 2106567 + 795 264 FALSE

Rv1858 (Molybdenum transport system permease protein ModB (TC 3.A.1.8.1)) is predicted to be co-regulated in modules bicluster_0073 with residual 0.60 and bicluster_0583 with residual 0.57.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.00 for bicluster_0073 and 0.00 and 2.80 for bicluster_0583 respectively.

These modules are enriched for following go terms: O-acyltransferase activity.

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 11:45
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-18019 MT1906 1134
Product (LegacyBRC) Product (RefSeq)
Molybdenum transport system permease protein modB molbdenum-transport integral membrane protein ABC transporter
Operon # Operon
1216 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

ABC transporters

57
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608995 NP_216374.1 Run
GO:0016020

membrane

membrane

Details: 
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
GO Category: 
cellular_component
33
Total items in this category:  
GO:0005215

transporter activity

transporter activity

Details: 
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
GO Category: 
molecular_function
27
Total items in this category:  
GO:0006810

transport

transport

Details: 
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
GO Category: 
biological_process
28
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.130000 0.80

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: