Rv2104c

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2104c vapB37 CDS 2364527 2364781 - 255 84 FALSE

Rv2104c () is predicted to be co-regulated in modules bicluster_0180 with residual 0.54 and bicluster_0412 with residual 0.47.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 19,000.00 and 20,000.00 for bicluster_0180 and 0.29 and 2.60 for bicluster_0412 respectively.

These modules are enriched for following go terms: cellular macromolecule biosynthetic proc..., macromolecule biosynthetic process, regulation of transcription, DNA-depende..., regulation of RNA metabolic process, regulation of RNA biosynthetic process, regulation of biosynthetic process, regulation of gene expression, regulation of macromolecule biosynthetic..., regulation of cellular biosynthetic proc..., regulation of cellular macromolecule bio..., regulation of nucleobase-containing comp..., regulation of nitrogen compound metaboli..., regulation of cellular metabolic process, regulation of macromolecule metabolic pr..., regulation of primary metabolic process, transcription, DNA-dependent, regulation of metabolic process, RNA biosynthetic process, nucleic acid metabolic process, nucleic acid binding transcription facto..., sequence-specific DNA binding transcript... .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Putative uncharacterized protein
Operon # Operon
1377 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics
Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15609241 NP_216620.1 Run
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.640000 1.19

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: