Rv2188c Poly(glycerol-phosphate) alpha-glucosyltransferase (EC 2.4.1.52)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2188c pimB Poly(glycerol-phosphate) alpha-glucosyltransferase (EC 2.4.1.52) CDS 2449993 2451150 - 1 158 385 FALSE

Rv2188c (Poly(glycerol-phosphate) alpha-glucosyltransferase (EC 2.4.1.52)) is predicted to be co-regulated in modules bicluster_0098 with residual 0.64 and bicluster_0352 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.00 for bicluster_0098 and 0.01 and 2,900.00 for bicluster_0352 respectively.

These modules are enriched for following go terms: cellular biosynthetic process, organic substance biosynthetic process, translational elongation, macromolecule metabolic process, biosynthetic process, intracellular, macromolecular complex, translation elongation factor activity.

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

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Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 5 of 5
ChipSeq TF Differential Expression Distance Expression pvalue Type
Two component transcriptional regulatory protein DevR
No -40 -0.17 0.0794887 CDS
Two component transcriptional regulatory protein DevR
No 66 -0.17 0.0794887 Antisense.TSS
No -36 0.02 0.967153 Internal.TSS
Transcriptional regulator, MarR family
No -10 -0.05 0.922068 CDS
Transcriptional regulator, ArsR family
No -25 0.28 0.0171152 CDS
Motif 1 Motif 2 Residual
bicluster_0098
e.value: 
0
Motif Bicluster: 
e.value: 
3.3e-26
Motif Bicluster: 
0.64
bicluster_0352
e.value: 
0.0081
Motif Bicluster: 
e.value: 
2900
Motif Bicluster: 
0.50
Product (LegacyBRC) Product (RefSeq)
Putative uncharacterized protein
Operon # Operon
1434 Rv2188c
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
57116954 NP_216704.2 Run
GO:0000030

mannosyltransferase activity

mannosyltransferase activity

Details: 
Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
GO Category: 
molecular_function
3
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0009247

glycolipid biosynthetic process

glycolipid biosynthetic process

Details: 
The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).
GO Category: 
biological_process
17
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.