Rv2465c Ribose 5-phosphate isomerase B (EC 5.3.1.6) / Galactose 6-phosphate isomerase

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2465c rpiB Ribose 5-phosphate isomerase B (EC 5.3.1.6) / Galactose 6-phosphate isomerase CDS 2767671 2768159 - 489 162 FALSE

Rv2465c (Ribose 5-phosphate isomerase B (EC 5.3.1.6) / Galactose 6-phosphate isomerase) is predicted to be co-regulated in modules bicluster_0170 with residual 0.37 and bicluster_0600 with residual 0.49.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 1,600.00 and 1,700.00 for bicluster_0170 and 2,200.00 and 750.00 for bicluster_0600 respectively.

These modules are enriched for following go terms: .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

BASS Score Distance to Tuberculist Start Codon Internal TSS Re-Annotated Start Tuberculist Annotated Start
-1.014 9 2768150 2768150 2768159
Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 2 of 2
ChipSeq TF Differential Expression Distance Expression pvalue Type
Repressed -28 -1.29 0.00000000764 Internal.TSS
Repressed -37 -1.29 0.00000000764 CDS
Motif 1 Motif 2 Residual
bicluster_0170
e.value: 
1600
Motif Bicluster: 
e.value: 
1700
Motif Bicluster: 
0.37
bicluster_0600
e.value: 
2200
Motif Bicluster: 
e.value: 
750
Motif Bicluster: 
0.49
Product (LegacyBRC) Product (RefSeq)
Ribose-5-phosphate isomerase B ribose-5-phosphate isomerase B
Operon # Operon
1625 Rv2464c - Rv2465c
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Pentose phosphate pathway

19
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  

KEGG

Biosynthesis of secondary metabolites

326
Total items in this category:  

KEGG

Microbial metabolism in diverse environments

296
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
57116993 YP_177884.1 Run
GO:0004751

ribose-5-phosphate isomerase activity

ribose-5-phosphate isomerase activity

Details: 
Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate.
GO Category: 
molecular_function
1
Total items in this category:  
GO:0005576

extracellular region

extracellular region

Details: 
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO Category: 
cellular_component
272
Total items in this category:  
GO:0042803

protein homodimerization activity

protein homodimerization activity

Details: 
Interacting selectively and non-covalently with an identical protein to form a homodimer.
GO Category: 
molecular_function
83
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.