Rv2523c Holo-[acyl-carrier protein] synthase (EC

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2523c acpS Holo-[acyl-carrier protein] synthase (EC CDS 2839538 2839930 - 393 130 FALSE

Rv2523c (Holo-[acyl-carrier protein] synthase (EC is predicted to be co-regulated in modules bicluster_0237 with residual 0.49 and bicluster_0342 with residual 0.54.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 9.90 and 3,200.00 for bicluster_0237 and 37.00 and 4,800.00 for bicluster_0342 respectively.

These modules are enriched for following go terms: fatty acid biosynthetic process, monocarboxylic acid biosynthetic process, fatty acid metabolic process branched-chain amino acid biosynthetic p..., branched-chain amino acid metabolic proc..., cytosol, cytosolic part.

This gene is found to be for growth on cholesterol.

Mutant available?:

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Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
Motif Bicluster: 
Motif Bicluster: 
Motif Bicluster: 
Motif Bicluster: 
Product (LegacyBRC) Product (RefSeq)
Holo-[acyl-carrier-protein] synthase 4'-phosphopantetheinyl transferase
Operon # Operon
1661 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Holo-[acyl-carrier-protein] synthase Pantothenate and CoA biosynthesis
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Pantothenate and CoA biosynthesis

Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15609660 NP_217039.1 Run
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: