Rv2588c Preprotein translocase subunit YajC (TC 3.A.5.1.1)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2588c yajC Preprotein translocase subunit YajC (TC 3.A.5.1.1) CDS 2915846 2916193 - 348 115 FALSE

Rv2588c (Preprotein translocase subunit YajC (TC 3.A.5.1.1)) is predicted to be co-regulated in modules bicluster_0097 with residual 0.50 and bicluster_0274 with residual 0.46.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.37 for bicluster_0097 and 0.00 and 0.00 for bicluster_0274 respectively.

These modules are enriched for following go terms: monovalent inorganic cation transmembran..., inorganic cation transmembrane transport... .

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 13:57
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-14707 MT2665 1175
Product (LegacyBRC) Product (RefSeq)
Uncharacterized protein Rv2588c_MT2665 preprotein translocase subunit YajC
Operon # Operon
1699
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Protein export

16
Total items in this category:  

KEGG

Bacterial secretion system

14
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15609725 NP_217104.1 Run
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.490000 3.63

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: