Rv2610c Phosphatidylinositol alpha-mannosyltransferase (EC 2.4.1.57)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2610c pimA Phosphatidylinositol alpha-mannosyltransferase (EC 2.4.1.57) CDS 2937865 2939001 - 1 137 378 TRUE

Rv2610c (Phosphatidylinositol alpha-mannosyltransferase (EC 2.4.1.57)) is predicted to be co-regulated in modules bicluster_0034 with residual 0.54 and bicluster_0351 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 57.00 and 260.00 for bicluster_0034 and 0.00 and 0.02 for bicluster_0351 respectively.

These modules are enriched for following go terms: phosphotransferase activity, for other s... .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 10 of 14
Gene Target Differential Expression Distance Expression pvalue Type
NA 53 CDS
NA -66 Primary.TSS
Iron-sulfur cluster regulator SufR
NA -12 Internal.TSS
Iron-sulfur cluster regulator SufR
NA 60 CDS
NA -25 Internal.TSS
No results were found NA -25 Primary.TSS
NA -25 Antisense.TSS
NA -83 CDS
Putative transcriptional regulatory protein
NA -16 Primary.TSS
Possible methyltransferase (Methylase)
NA -67 CDS
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0034
e.value: 
57
Motif Bicluster: 
e.value: 
260
Motif Bicluster: 
0.54
bicluster_0351
e.value: 
0.000064
Motif Bicluster: 
e.value: 
0.02
Motif Bicluster: 
0.53
Product (LegacyBRC) Product (RefSeq)
Phosphatidylinositol alpha-mannosyltransferase alpha-mannosyltransferase PIMA
Operon # Operon
1712 Rv2609c - Rv2610c - Rv2611c - Rv2612c - Rv2613c - Rv2614c
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15609747 NP_217126.1 Run
GO:0000030

mannosyltransferase activity

mannosyltransferase activity

Details: 
Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
GO Category: 
molecular_function
3
Total items in this category:  
GO:0000287

magnesium ion binding

magnesium ion binding

Details: 
Interacting selectively and non-covalently with magnesium (Mg) ions.
GO Category: 
molecular_function
52
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0043750

phosphatidylinositol alpha-mannosyltransferase activity

phosphatidylinositol alpha-mannosyltransferase activity

Details: 
Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol.
GO Category: 
molecular_function
1
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Experiment UCSC Genome Browser
Rv2610c_B180 UCSC Browser Tracks
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.