Rv2610c Phosphatidylinositol alpha-mannosyltransferase (EC 2.4.1.57)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2610c pimA Phosphatidylinositol alpha-mannosyltransferase (EC 2.4.1.57) CDS 2937865 2939001 - 1 137 378 TRUE

Rv2610c (Phosphatidylinositol alpha-mannosyltransferase (EC 2.4.1.57)) is predicted to be co-regulated in modules bicluster_0034 with residual 0.54 and bicluster_0351 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 57.00 and 260.00 for bicluster_0034 and 0.00 and 0.02 for bicluster_0351 respectively.

These modules are enriched for following go terms: phosphotransferase activity, for other s... .

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 10 of 14
Gene Target Differential Expression Distance Expression pvalue Type
NA 53 CDS
NA -66 Primary.TSS
Iron-sulfur cluster regulator SufR
NA -12 Internal.TSS
Iron-sulfur cluster regulator SufR
NA 60 CDS
NA -25 Internal.TSS
No results were found NA -25 Primary.TSS
NA -25 Antisense.TSS
NA -83 CDS
Putative transcriptional regulatory protein
NA -16 Primary.TSS
Possible methyltransferase (Methylase)
NA -67 CDS
Product (LegacyBRC) Product (RefSeq)
Phosphatidylinositol alpha-mannosyltransferase alpha-mannosyltransferase PIMA
Operon # Operon
1712 - - - - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15609747 NP_217126.1 Run
GO:0000030

mannosyltransferase activity

mannosyltransferase activity

Details: 
Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
GO Category: 
molecular_function
3
Total items in this category:  
GO:0000287

magnesium ion binding

magnesium ion binding

Details: 
Interacting selectively and non-covalently with magnesium (Mg) ions.
GO Category: 
molecular_function
52
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0043750

phosphatidylinositol alpha-mannosyltransferase activity

phosphatidylinositol alpha-mannosyltransferase activity

Details: 
Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol.
GO Category: 
molecular_function
1
Total items in this category:  
No TFOE experiment results were found
Experiment UCSC Genome Browser
Rv2610c_B180 UCSC Browser Tracks
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: