Rv2641 Lactoylglutathione lyase (EC 4.4.1.5)

Summary

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2641 cadI Lactoylglutathione lyase (EC 4.4.1.5) CDS 2965939 2966397 + 459 152 FALSE

Rv2641 (Lactoylglutathione lyase (EC 4.4.1.5)) is predicted to be co-regulated in modules bicluster_0008 with residual 0.62 and bicluster_0347 with residual 0.45.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.00 for bicluster_0008 and 250.00 and 510.00 for bicluster_0347 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Cadmium-induced protein cadI cadmium inducible protein CADI
Operon # Operon
1736
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Lactoylglutathione lyase Pyruvate metabolism
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15609778 NP_217157.1 Run
GO:0046686

response to cadmium ion

response to cadmium ion

Details: 
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
GO Category: 
biological_process
2
Total items in this category:  
No TFOE experiment results were found

Quantitative Proteomics Data

t-test p-value Cholesterol/Glycerol Ratio
0.500000 1.06

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: