Rv2692 Trk system potassium uptake protein TrkA

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2692 ceoC Trk system potassium uptake protein TrkA CDS 3010024 3010686 + 663 220 FALSE

Rv2692 (Trk system potassium uptake protein TrkA) is predicted to be co-regulated in modules bicluster_0079 with residual 0.57 and bicluster_0468 with residual 0.58.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.70 and 11.00 for bicluster_0079 and 14.00 and 16.00 for bicluster_0468 respectively.

These modules are enriched for following go terms: potassium ion transport .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Trk system potassium uptake protein trkA TRK system potassium uptake protein CEOC
Operon # Operon
1764 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
57117016 YP_177901.1 Run
GO:0008324

cation transmembrane transporter activity

cation transmembrane transporter activity

Details: 
Catalysis of the transfer of cation from one side of the membrane to the other.
GO Category: 
molecular_function
6
Total items in this category:  
GO:0006813

potassium ion transport

potassium ion transport

Details: 
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO Category: 
biological_process
5
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.460000 6.69

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: