Rv2744c Phage shock protein A (IM30) , suppresses sigma54-dependent transcription

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2744c 35kd_ag Phage shock protein A (IM30) , suppresses sigma54-dependent transcription CDS 3057251 3058063 - 813 270 FALSE

Rv2744c (Phage shock protein A (IM30) , suppresses sigma54-dependent transcription) is predicted to be co-regulated in modules bicluster_0073 with residual 0.60 and bicluster_0158 with residual 0.52.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.00 for bicluster_0073 and 20,000.00 and 33,000.00 for bicluster_0158 respectively.

These modules are enriched for following go terms: pyruvate dehydrogenase activity, pyruvate dehydrogenase (acetyl-transferr..., oxidoreductase activity, acting on the a....

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

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Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
HTH-type transcriptional regulator
No -53 -0.06 0.759431 Primary.TSS
Motif 1 Motif 2 Residual
bicluster_0073
e.value: 
0.0000015
Motif Bicluster: 
e.value: 
0.000047
Motif Bicluster: 
0.60
bicluster_0158
e.value: 
20000
Motif Bicluster: 
e.value: 
33000
Motif Bicluster: 
0.52
Product (LegacyBRC) Product (RefSeq)
35 kDa protein
Operon # Operon
1805 Rv2743c - Rv2744c
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
57117019 YP_177903.1 Run
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.290000 0.98

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.