Rv2905 Putative lipoprotein lppW precursor

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2905 lppW Putative lipoprotein lppW precursor CDS 3214628 3215572 + 945 314 FALSE

Rv2905 (Putative lipoprotein lppW precursor) is predicted to be co-regulated in modules bicluster_0064 with residual 0.44 and bicluster_0227 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 500.00 and 2,500.00 for bicluster_0064 and 89.00 and 1,900.00 for bicluster_0227 respectively.

These modules are enriched for following go terms: protein secretion, secretion by cell, secretion, establishment of localization in cell, cellular localization, antibiotic metabolic process, drug metabolic process, protein transport, establishment of protein localization .

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 14:41
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-14755 MT2973 77
Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 8 of 8
ChipSeq TF Differential Expression Distance Expression pvalue Type
Sporulation regulatory protein WhiB
No -25 0.58 0.0000284 Primary.TSS
Organic hydroperoxide resistance transcriptional regulator
No 70 -0.19 0.389386 Primary.TSS
WhiB-type transcription regulator
No -34 0.28 0.999973 Primary.TSS
DNA-binding response regulator TrcR
Repressed -7 -0.87 0.000000000091 Primary.TSS
DNA-binding response regulator
Induced -47 0.84 0.00000000000017 Primary.TSS
Repressed -49 -0.68 0.0000000129 Primary.TSS
Transcriptional regulator, TetR family
Repressed 16 -0.87 0.0000000000735 Primary.TSS
Transcriptional regulatory protein
Repressed 6 -0.62 0.00000115 Primary.TSS
Motif 1 Motif 2 Residual
bicluster_0064
e.value: 
500
Motif Bicluster: 
e.value: 
2500
Motif Bicluster: 
0.44
bicluster_0227
e.value: 
89
Motif Bicluster: 
e.value: 
1900
Motif Bicluster: 
0.50
Product (LegacyBRC) Product (RefSeq)
Putative lipoprotein lppW alanine rich lipoprotein LppW
Operon # Operon
1898
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15610042 NP_217421.1 Run
GO:0005576

extracellular region

extracellular region

Details: 
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO Category: 
cellular_component
272
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.900000 2.56

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: