Rv2912c Transcriptional regulator, TetR family

Product Feature Type Start End Strand Length AA Length is TF
Rv2912c Transcriptional regulator, TetR family CDS 3219274 3219861 - 588 195 TRUE

Rv2912c (Transcriptional regulator, TetR family) is predicted to be co-regulated in modules bicluster_0190 with residual 0.49 and bicluster_0595 with residual 0.62.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 4.80 for bicluster_0190 and 0.17 and 3,400.00 for bicluster_0595 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 2 of 2
Gene Target Differential Expression Distance Expression pvalue Type
N-acyl-D-glutamate amidohydrolase
Repressed 22 -1.31 0.000426941 Internal.TSS
N-acyl-D-glutamate amidohydrolase
Repressed 6 -1.31 0.000426941 CDS
Product (LegacyBRC) Product (RefSeq)
Uncharacterized HTH-type transcriptional regulator Rv2912c_MT2980 TetR family transcriptional regulator
Operon # Operon
1902 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15610049 NP_217428.1 Run



The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO Category: 
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
BioProject Accession GEO Series References Repository Sample Method Sample Type
PRJNA254351 GSM1426886 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426887 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426888 GSE59086 25232098 GEO Tiling Array RNA
Experiment UCSC Genome Browser
Rv2912c_B629 UCSC Browser Tracks
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.470000 1.18

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated: 0.176586
p-value INH: 0.725941
Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D0U 27 0 0.00 13.74 U
D3I 3 3 3.83 14.06 I
D3U 3 3 3.83 13.67 U
D5I 9 5 6.00 13.84 I
D5U 17 5 6.00 13.76 U
D7I 18 7 8.14 13.90 I
D7U 19 7 8.14 14.34 U
D14I 4 14 15.63 13.42 I
D14U 4 14 15.63 14.23 U
D17I 3 17 19.15 12.30 I
D17U 3 17 19.15 13.84 U
D21I 4 21 23.23 12.03 I
D21U 4 21 23.23 14.06 U
D24I 3 24 26.60 10.79 I
D24U 3 24 26.60 13.71 U
D28I 4 28 30.61 10.75 I
D28U 4 28 30.61 13.74 U