Rv2921c Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2921c ftsY Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1) CDS 3232871 3234139 - 1 269 422 FALSE

Rv2921c (Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1)) is predicted to be co-regulated in modules bicluster_0252 with residual 0.55 and bicluster_0376 with residual 0.43.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 930.00 and 3,100.00 for bicluster_0252 and 3,100.00 and 24,000.00 for bicluster_0376 respectively.

These modules are enriched for following go terms: regulation of cell shape, regulation of anatomical structure morph..., regulation of cell morphogenesis, regulation of developmental process, cell morphogenesis, anatomical structure morphogenesis, developmental process, cellular component morphogenesis, single-organism developmental process, anatomical structure development, cellular developmental process, regulation of cellular component organiz..., cellular component organization .

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, TetR family
No 61 -0.01 0.982244 CDS
Motif 1 Motif 2 Residual
bicluster_0252
e.value: 
930
Motif Bicluster: 
e.value: 
3100
Motif Bicluster: 
0.55
bicluster_0376
e.value: 
3100
Motif Bicluster: 
e.value: 
24000
Motif Bicluster: 
0.43
Product (LegacyBRC) Product (RefSeq)
Cell division protein ftsY homolog cell division protein FtsY
Operon # Operon
1908
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Protein export

16
Total items in this category:  

KEGG

Bacterial secretion system

14
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15610058 NP_217437.1 Run
GO:0006614

SRP-dependent cotranslational protein targeting to membrane

SRP-dependent cotranslational protein targeting to membrane

Details: 
The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
GO Category: 
biological_process
2
Total items in this category:  
GO:0003723

RNA binding

RNA binding

Details: 
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
GO Category: 
molecular_function
16
Total items in this category:  
GO:0009986

cell surface

cell surface

Details: 
The external part of the cell wall and/or plasma membrane.
GO Category: 
cellular_component
4
Total items in this category:  
GO:0005525

GTP binding

GTP binding

Details: 
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
GO Category: 
molecular_function
18
Total items in this category:  
GO:0016020

membrane

membrane

Details: 
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
GO Category: 
cellular_component
33
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: