Rv2958c UDP-glucoronosyl and UDP-glucosyltransferases family protein

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv2958c UDP-glucoronosyl and UDP-glucosyltransferases family protein CDS 3310714 3312000 - 1 287 428 FALSE

Rv2958c (UDP-glucoronosyl and UDP-glucosyltransferases family protein) is predicted to be co-regulated in modules bicluster_0253 with residual 0.45 and bicluster_0479 with residual 0.49.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 18.00 and 8,100.00 for bicluster_0253 and 1,900.00 and 4,400.00 for bicluster_0479 respectively.

These modules are enriched for following go terms: substrate-specific transmembrane transpo..., substrate-specific transporter activity, hydrogen ion transmembrane transporter a..., cation transmembrane transporter activit..., transmembrane transporter activity, monovalent inorganic cation transmembran....

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 14:41
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-15457 MT3034 1536
Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, PadR family
No -105 0.73 0.263291 Internal.TSS
Motif 1 Motif 2 Residual
bicluster_0253
e.value: 
18
Motif Bicluster: 
e.value: 
8100
Motif Bicluster: 
0.45
bicluster_0479
e.value: 
1900
Motif Bicluster: 
e.value: 
4400
Motif Bicluster: 
0.49
Product (LegacyBRC) Product (RefSeq)
PGL_p-HBAD biosynthesis glycosyltransferase Rv2958c_MT3034 glycosyl transferase
Operon # Operon
1928
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15610095 NP_217474.1 Run
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0009247

glycolipid biosynthetic process

glycolipid biosynthetic process

Details: 
The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).
GO Category: 
biological_process
17
Total items in this category:  
GO:0009405

pathogenesis

pathogenesis

Details: 
The set of specific processes that generate the ability of an organism to cause disease in another.
GO Category: 
biological_process
65
Total items in this category:  
GO:0016758

transferase activity, transferring hexosyl groups

transferase activity, transferring hexosyl groups

Details: 
Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).
GO Category: 
molecular_function
7
Total items in this category:  
GO:0020012

evasion or tolerance of host immune response

evasion or tolerance of host immune response

Details: 
Any process, either active or passive, by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO Category: 
biological_process
3
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.860000 1.94

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: