Rv2962c PGL/p-HBAD biosynthesis rhamnosyltransferase

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv2962c PGL/p-HBAD biosynthesis rhamnosyltransferase CDS 3313773 3315122 - 1 350 449 FALSE

Rv2962c (PGL/p-HBAD biosynthesis rhamnosyltransferase) is predicted to be co-regulated in modules bicluster_0185 with residual 0.52 and bicluster_0483 with residual 0.60.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 1,500.00 and 29,000.00 for bicluster_0185 and 0.00 and 0.02 for bicluster_0483 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

BASS Score Distance to Tuberculist Start Codon Internal TSS New Internal UTR Re-Annotated Start Tuberculist Annotated Start
-0.783 32 3315090 121 3314969 3315122
Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0185
e.value: 
1500
Motif Bicluster: 
e.value: 
29000
Motif Bicluster: 
0.52
bicluster_0483
e.value: 
0.00031
Motif Bicluster: 
e.value: 
0.018
Motif Bicluster: 
0.60
Product (LegacyBRC) Product (RefSeq)
PGL_p-HBAD biosynthesis rhamnosyltransferase glycosyl transferase
Operon # Operon
1932
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15610099 NP_217478.1 Run
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0009247

glycolipid biosynthetic process

glycolipid biosynthetic process

Details: 
The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).
GO Category: 
biological_process
17
Total items in this category:  
GO:0016758

transferase activity, transferring hexosyl groups

transferase activity, transferring hexosyl groups

Details: 
Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).
GO Category: 
molecular_function
7
Total items in this category:  
GO:0020012

evasion or tolerance of host immune response

evasion or tolerance of host immune response

Details: 
Any process, either active or passive, by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO Category: 
biological_process
3
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.950000 9.12

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: