Rv3140 Probable acyl-CoA dehydrogenase (EC 1.3.99.3)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3140 fadE23 Probable acyl-CoA dehydrogenase (EC 1.3.99.3) CDS 3506790 3507995 + 1 206 401 FALSE

Rv3140 (Probable acyl-CoA dehydrogenase (EC 1.3.99.3)) is predicted to be co-regulated in modules bicluster_0156 with residual 0.52 and bicluster_0593 with residual 0.58.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 180.00 and 890.00 for bicluster_0156 and 4,900.00 and 7,400.00 for bicluster_0593 respectively.

These modules are enriched for following go terms: .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 4 of 4
ChipSeq TF Differential Expression Distance Expression pvalue Type
No 9 -0.18 0.999734 CDS
WhiB family transcriptional regulator
No 19 0.05 0.938847 CDS
Arsenical resistance operon repressor
No -4 -0.35 0.586101 CDS
transcriptional regulator, ArsR family
Induced 3 1.09 0.000000535 CDS
Motif 1 Motif 2 Residual
bicluster_0156
e.value: 
180
Motif Bicluster: 
e.value: 
890
Motif Bicluster: 
0.52
bicluster_0593
e.value: 
4900
Motif Bicluster: 
e.value: 
7400
Motif Bicluster: 
0.58
Product (LegacyBRC) Product (RefSeq)
PROBABLE ACYL-CoA DEHYDROGENASE FADE23 acyl-CoA dehydrogenase FADE23
Operon # Operon
2052 Rv3139 - Rv3140
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Fatty acid metabolism

51
Total items in this category:  

KEGG

Valine, leucine and isoleucine degradation

60
Total items in this category:  

KEGG

beta-Alanine metabolism

37
Total items in this category:  

KEGG

Propanoate metabolism

62
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  

KEGG

Biosynthesis of secondary metabolites

326
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15610276 NP_217656.1 Run
GO:0003995

acyl-CoA dehydrogenase activity

acyl-CoA dehydrogenase activity

Details: 
Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
GO Category: 
molecular_function
8
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.040000 0.30

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.