Rv3230c Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv3230c Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 CDS 3607112 3608254 - 1 143 380 FALSE

Rv3230c (Flavodoxin reductases (ferredoxin-NADPH reductases) family 1) is predicted to be co-regulated in modules bicluster_0202 with residual 0.55 and bicluster_0374 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.01 and 150.00 for bicluster_0202 and 0.01 and 3,200.00 for bicluster_0374 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
HYPOTHETICAL OXIDOREDUCTASE oxidoreductase
Operon # Operon
2115
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15610366 NP_217747.1 Run
GO:0016491

oxidoreductase activity

oxidoreductase activity

Details: 
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO Category: 
molecular_function
12
Total items in this category:  
GO:0006118

electron transport

electron transport

Details: 
OBSOLETE. The transport of electrons from an electron donor to an electron acceptor.
GO Category: 
biological_process
11
Total items in this category:  
GO:0005506

iron ion binding

iron ion binding

Details: 
Interacting selectively and non-covalently with iron (Fe) ions.
GO Category: 
molecular_function
13
Total items in this category:  
GO:0009055

electron carrier activity

electron carrier activity

Details: 
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system.
GO Category: 
molecular_function
10
Total items in this category:  
GO:0005515

protein binding

protein binding

Details: 
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO Category: 
molecular_function
135
Total items in this category:  
GO:0009055

electron carrier activity

electron carrier activity

Details: 
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system.
GO Category: 
molecular_function
10
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: