Rv3441c Phosphoglucosamine mutase (EC 5.4.2.10)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3441c mrsA Phosphoglucosamine mutase (EC 5.4.2.10) CDS 3860024 3861370 - 1 347 448 FALSE

Rv3441c (Phosphoglucosamine mutase (EC 5.4.2.10)) is predicted to be co-regulated in modules bicluster_0304 with residual 0.58 and bicluster_0588 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.36 and 78.00 for bicluster_0304 and 0.00 and 0.00 for bicluster_0588 respectively.

These modules are enriched for following go terms: cellular ketone metabolic process .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

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Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 7 of 7
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, PadR family
No 36 -0.07 0.791575 Primary.TSS
Transcriptional regulator, AsnC family
No 66 -0.02 0.978693 Primary.TSS
No 30 0.02 0.929798 Primary.TSS
Transcriptional regulator, ArsR family
No 28 -0.04 0.792706 Primary.TSS
Transcriptional regulator, ArsR family
No 49 -0.12 0.430642 Primary.TSS
transcriptional regulator, ArsR family
No 68 -0.07 0.453822 Primary.TSS
Transcriptional regulator, AraC family
No -32 -0.06 0.956347 Primary.TSS
Motif 1 Motif 2 Residual
bicluster_0304
e.value: 
0.36
Motif Bicluster: 
e.value: 
78
Motif Bicluster: 
0.58
bicluster_0588
e.value: 
0
Motif Bicluster: 
e.value: 
0
Motif Bicluster: 
0.50
Product (LegacyBRC) Product (RefSeq)
Phosphoglucosamine mutase phospho-sugar mutase / MRSA protein
Operon # Operon
2250 Rv3441c
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Phosphoglucosamine mutase Amino sugar and nucleotide sugar metabolism
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Amino sugar and nucleotide sugar metabolism

28
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15610577 NP_217958.1 Run
GO:0008966

phosphoglucosamine mutase activity

phosphoglucosamine mutase activity

Details: 
Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate.
GO Category: 
molecular_function
1
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.