Rv3634c UDP-glucose 4-epimerase (EC 5.1.3.2)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3634c galE1 UDP-glucose 4-epimerase (EC 5.1.3.2) CDS 4072667 4073611 - 945 314 FALSE

Rv3634c (UDP-glucose 4-epimerase (EC 5.1.3.2)) is predicted to be co-regulated in modules bicluster_0414 with residual 0.45 and bicluster_0493 with residual 0.66.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 65.00 and 550.00 for bicluster_0414 and 0.02 and 25.00 for bicluster_0493 respectively.

These modules are enriched for following go terms: .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0414
e.value: 
65
Motif Bicluster: 
e.value: 
550
Motif Bicluster: 
0.45
bicluster_0493
e.value: 
0.017
Motif Bicluster: 
e.value: 
25
Motif Bicluster: 
0.66
Product (LegacyBRC) Product (RefSeq)
UDP-GLUCOSE 4-EPIMERASE GALE1 [GALACTOWALDENASE] [UDP-GALACTOSE 4-EPIMERASE] [URIDINE DIPHOSPHATE GALACTOSE 4-EPIMERASE] [URIDINE DIPHOSPHO-GALACTOSE 4-EPIMERASE] UDP-glucose 4-epimerase GALE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase)
Operon # Operon
2364 Rv3634c
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Galactose metabolism

14
Total items in this category:  

KEGG

Amino sugar and nucleotide sugar metabolism

28
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
57117137 NP_215015.2 Run
GO:0003978

UDP-glucose 4-epimerase activity

UDP-glucose 4-epimerase activity

Details: 
Catalysis of the reaction: UDP-glucose = UDP-galactose.
GO Category: 
molecular_function
2
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.