Rv3761c Acyl-CoA dehydrogenase FadE36 (EC 1.3.99.-)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3761c fadE36 Acyl-CoA dehydrogenase FadE36 (EC 1.3.99.-) CDS 4205862 4206917 - 1 056 351 FALSE

Rv3761c (Acyl-CoA dehydrogenase FadE36 (EC 1.3.99.-)) is predicted to be co-regulated in modules bicluster_0225 with residual 0.50 and bicluster_0499 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.00 for bicluster_0225 and 560.00 and 11,000.00 for bicluster_0499 respectively.

These modules are enriched for following go terms: aspartic-type endopeptidase activity, aspartic-type peptidase activity.

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0225
e.value: 
0.000000000013
Motif Bicluster: 
e.value: 
0.000000000015
Motif Bicluster: 
0.50
bicluster_0499
e.value: 
560
Motif Bicluster: 
e.value: 
11000
Motif Bicluster: 
0.50
Product (LegacyBRC) Product (RefSeq)
POSSIBLE ACYL-CoA DEHYDROGENASE FADE36 acyl-CoA dehydrogenase
Operon # Operon
2457
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Geraniol degradation

52
Total items in this category:  

KEGG

Naphthalene degradation

40
Total items in this category:  

KEGG

Biosynthesis of secondary metabolites

326
Total items in this category:  

KEGG

Microbial metabolism in diverse environments

296
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15610897 NP_218278.1 Run
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0042783

active evasion of host immune response

active evasion of host immune response

Details: 
Any mechanism of immune avoidance that directly affects the host immune system, e.g. blocking any stage in host MHC class I and II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO Category: 
biological_process
20
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.210000 0.82

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: