Rv3855 Transcriptional repressor EthR, TetR family

Rv3855 (Transcriptional repressor EthR, TetR family) is predicted to be co-regulated in modules bicluster_0129 with residual 0.53 and bicluster_0478 with residual 0.49.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 2.40 for bicluster_0129 and 0.00 and 0.09 for bicluster_0478 respectively.

These modules are enriched for following go terms: single-organism process, transport, establishment of localization, localization, arsenite transmembrane transporter activ..., anion transmembrane transporter activity.

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 11 - 20 of 24
Gene Target Differential Expression Distance Expression pvalue Type
FIG055075: Possibly a cell division protein, antigen 84 in Mycobacteria
No 65 0.05 0.950882 Primary.TSS
No -143 -0.03 0.988662 CDS
No -4 0.1 0.963583 Internal.TSS
No -30 0.1 0.963583 CDS
DNA-binding protein, CopG family
No -5 0.73 0.645772 Primary.TSS
Transcriptional regulator, AsnC family
No 45 0.02 0.990244 Internal.TSS
Transcriptional regulator, AsnC family
No 3 0.02 0.990244 CDS
Alanine dehydrogenase (EC 1.4.1.1)
No -42 0.06 0.975094 Primary.TSS
No 1 -0.42 0.832883 Primary.TSS
Probable L-lysine-epsilon aminotransferase (EC 2.6.1.36) (L-lysine aminotransferase) (Lysine 6-aminotransferase)
No 42 -0.1 0.955181 Primary.TSS
not assigned to any KEGG Pathway.
GO:0005829

cytosol

cytosol

Details: 
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO Category: 
cellular_component
371
Total items in this category:  
GO:0042803

protein homodimerization activity

protein homodimerization activity

Details: 
Interacting selectively and non-covalently with an identical protein to form a homodimer.
GO Category: 
molecular_function
83
Total items in this category:  
GO:0045892

negative regulation of transcription, DNA-dependent

negative regulation of transcription, DNA-dependent

Details: 
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-dependent transcription.
GO Category: 
biological_process
10
Total items in this category:  
GO:0046677

response to antibiotic

response to antibiotic

Details: 
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
GO Category: 
biological_process
15
Total items in this category:  
GO:0051260

protein homooligomerization

protein homooligomerization

Details: 
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
GO Category: 
biological_process
31
Total items in this category:  
No TFOE experiment results were found

TRIP log2 fold abundance change

NA
Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D0U 27 0 0.00 13.82 U
D3I 3 3 3.83 13.36 I
D3U 3 3 3.83 13.28 U
D5I 9 5 6.00 13.62 I
D5U 17 5 6.00 13.44 U
D7I 18 7 8.14 13.50 I
D7U 19 7 8.14 13.24 U
D14I 4 14 15.63 13.21 I
D14U 4 14 15.63 13.43 U
D17I 3 17 19.15 12.86 I
D17U 3 17 19.15 13.33 U
D21I 4 21 23.23 12.79 I
D21U 4 21 23.23 13.49 U
D24I 3 24 26.60 11.76 I
D24U 3 24 26.60 13.13 U
D28I 4 28 30.61 12.02 I
D28U 4 28 30.61 13.15 U