Rv3881c

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3881c espB CDS 4360543 4361925 - 1 383 460 FALSE

Rv3881c () is predicted to be co-regulated in modules bicluster_0243 with residual 0.50 and bicluster_0559 with residual 0.55.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.06 and 2,000.00 for bicluster_0243 and 0.00 and 0.00 for bicluster_0559 respectively.

These modules are enriched for following go terms: Mo-molybdopterin cofactor biosynthetic p..., Mo-molybdopterin cofactor metabolic proc..., molybdopterin cofactor biosynthetic proc..., molybdopterin cofactor metabolic process, prosthetic group metabolic process.

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 8 of 8
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, AsnC family
No 26 -0.15 0.837025 CDS
Transcriptional regulator, PadR family
No 13 0 0.991765 CDS
Transcriptional regulator WhiB-like WhiB6
Induced 1 1.24 1.03e-26 CDS
Transcriptional regulator, ArsR family
No 35 -0.13 0.285401 CDS
Mycofactocin system transcriptional regulator
No -17 0.22 0.999588 Internal.TSS
DNA-binding response regulator
No 43 0.25 0.0662234 CDS
transcriptional regulator, ArsR family
No 37 -0.05 0.663091 CDS
HTH-type transcriptional regulator
No 25 -0.25 0.14088 CDS
Motif 1 Motif 2 Residual
bicluster_0243
e.value: 
0.062
Motif Bicluster: 
e.value: 
2000
Motif Bicluster: 
0.50
bicluster_0559
e.value: 
0.0000032
Motif Bicluster: 
e.value: 
0.0049
Motif Bicluster: 
0.55
Product (LegacyBRC) Product (RefSeq)
Antigen MTB48
Operon # Operon
2537 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics
Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15611017 NP_218398.1 Run
GO:0005515

protein binding

protein binding

Details: 
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO Category: 
molecular_function
135
Total items in this category:  
GO:0005576

extracellular region

extracellular region

Details: 
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO Category: 
cellular_component
272
Total items in this category:  
GO:0009405

pathogenesis

pathogenesis

Details: 
The set of specific processes that generate the ability of an organism to cause disease in another.
GO Category: 
biological_process
65
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.630000 1.20

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: