Rv3883c serine protease

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3883c mycP1 serine protease CDS 4363417 4364757 - 1 341 446 FALSE

Rv3883c (serine protease) is predicted to be co-regulated in modules bicluster_0516 with residual 0.52 and bicluster_0574 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 2,900.00 and 10,000.00 for bicluster_0516 and 26.00 and 2,900.00 for bicluster_0574 respectively.

These modules are enriched for following go terms: anion transport, external encapsulating structure, cell periphery, transmembrane transporter activity, transporter activity .

This gene is found to be for growth on cholesterol.

Mutant available?:

BASS Score Distance to Tuberculist Start Codon Internal TSS New Primary UTR Primary TSS Re-Annotated Start Tuberculist Annotated Start
-0.5 789 4363968 47 4364834 4364787 4364757
Product (LegacyBRC) Product (RefSeq)
MEMBRANE-ANCHORED MYCOSIN MYCP1 [SERINE PROTEASE] [SUBTILISIN-LIKE PROTEASE] [SUBTILASE-LIKE] [MYCOSIN-1] membrane-anchored mycosin MYCP1 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-1)
Operon # Operon
2538 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Lysine degradation

Total items in this category:  


Biotin metabolism

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Metabolic pathways

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15611019 NP_218400.1 Run

plasma membrane

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
Total items in this category:  

cell surface

cell surface

The external part of the cell wall and/or plasma membrane.
GO Category: 
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.550000 0.98

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: