Publications
Systems-level analysis of innate immunity." Annu. Rev. Immunol.. 2014;32:547-77.
"Systems integration of innate and adaptive immunity." Vaccine. 2015;33(40):5241-8.
"Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung." Mucosal Immunol. 2017;10(2):555-564.
"Understanding and overcoming the barriers to T cell-mediated immunity against tuberculosis." Semin. Immunol.. 2014;26(6):578-87.
"A comprehensive map of genome-wide gene regulation in Mycobacterium tuberculosis." Scientific Data. 2015;2: - . (8.9 KB) (157.5 KB) (337.5 KB) (1.33 MB)
"Prospective Discrimination of Controllers From Progressors Early After Low-Dose Mycobacterium tuberculosis Infection of Cynomolgus Macaques using Blood RNA Signatures." J. Infect. Dis.. 2018;217(8):1318-1322.
"Host blood RNA signatures predict the outcome of tuberculosis treatment." Tuberculosis (Edinb). 2017;107:48-58.
"Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease." PLoS Pathog.. 2017;13(11):e1006687.
"Mapping and manipulating the Mycobacterium tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network." Genome Biol.. 2014;15(11):502. (19.36 MB) (20.15 MB)
"MiR-155-regulated molecular network orchestrates cell fate in the innate and adaptive immune response to Mycobacterium tuberculosis." Proc. Natl. Acad. Sci. U.S.A.. 2016;113(41):E6172-E6181.
"Flow Cytometry Analysis and Fluorescence-activated Cell Sorting of Myeloid Cells from Lung and Bronchoalveolar Lavage Samples from -infected Mice." Bio Protoc. 2020;10(10).
"Alveolar macrophages generate a noncanonical NRF2-driven transcriptional response in vivo." Sci Immunol. 2019;4(37).
"Landscape of coordinated immune responses to H1N1 challenge in humans." J Clin Invest. 2020;130(11):5800-5816.
"Ultra-low Dose Aerosol Infection of Mice with Mycobacterium tuberculosis More Closely Models Human Tuberculosis." Cell Host Microbe. 2020.
"Intricate Genetic Programs Controlling Dormancy in Mycobacterium tuberculosis." Cell Rep. 2020;31(4):107577.
"Network analysis identifies Rv0324 and Rv0880 as regulators of bedaquiline tolerance in Mycobacterium tuberculosis." Nat Microbiol. 2016;1(8):16078.
"A high-resolution network model for global gene regulation in Mycobacterium tuberculosis." Nucleic Acids Res.. 2014;42(18):11291-303.
"Path-seq identifies an essential mycolate remodeling program for mycobacterial host adaptation." Molecular Systems Biology. 2019;15:e8584.
" "Elucidation of host-pathogen protein-protein interactions to uncover mechanisms of host cell rewiring." Curr. Opin. Microbiol.. 2017;39:7-15.
"Contained Mycobacterium tuberculosis infection induces concomitant and heterologous protection." PLoS Pathog. 2020;16(7):e1008655.
"ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis." J. Exp. Med.. 2015;212(5):715-28.
"Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis." Cell Host Microbe. 2017;21(6):695-706.e5.
"The DNA-binding network of Mycobacterium tuberculosis." Nat Commun. 2015;6:5829.
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