P9WHG9 relA, Rv2583c, MTCY227.18 | MTB Network Portal

Summary

Source: Uniprot proteome:up000001584

Title	id	ORF names	Protein names	PubMed ID	Short	Synonyms	EnsemblBacteria
P9WHG9 RELA_MYCTU	Rv2583c GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I	MTCY227.18	Bifunctional (p)ppGpp synthase	9634230, 10375643, 10995231, 10940033, 16026164, 20529853	relA	relA, Rv2583c, MTCY227.18

Structure Details

Domain/Family Details

Domain	Domain Extent	InterPro	Pfam	ProDom	Region	Similarity	SUPFAM
Based on a mutagenesis study of the catalytic fragment (residues 1-394), the (p)ppGpp phosphohydrolase domain seems to encompass approximately the first 203 residues, while the (p)ppGpp synthase domain seems to be found between residues 87 and 394.	DOMAIN 53 150 HD., DOMAIN 662 736 ACT.		PF04607, PF02824			Belongs to the RelA/SpoT family., Contains 1 ACT domain., Contains 1 HD domain.	SSF81271

Domain/Family DBs

Gene3D	HAMAP	PANTHER	Pfam	PIRSF	PRINTS	ProDom	PROSITE	SMART	SUPFAM
3.10.20.30,			PF04607, PF02824				PS51671	SM00471, SM00954,	SSF81271

SSGCID Target Details

SSGCID ID

3D Details

PDB	Protein Model Portal

Pathway Details

EC number	KEGG KO	UniPathway
2.7.6.5, 3.1.7.2		Purine metabolism, ppGpp biosynthesis, ppGpp from GDP: step 1/1., Purine metabolism, ppGpp biosynthesis, ppGpp from GTP: step 1/2.

Phylogenetic

HOGENOM	KEGG KO	OMA	OrthoDB