Organism : Pseudomonas aeruginosa | Module List :
PA1242

hypothetical protein (NCBI)

CircVis
Functional Annotations (3)
Function System
Subtilisin-like serine proteases cog/ cog
subtilase activity go/ molecular_function
proteolysis go/ biological_process
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for PA1242
(Mouseover regulator name to see its description)

PA1242 is regulated by 39 influences and regulates 0 modules.
Regulators for PA1242 (39)
Regulator Module Operator
PA0864 280 tf
PA1347 280 tf
PA1351 280 tf
PA1374 280 tf
PA2121 280 tf
PA2896 280 tf
PA3006 280 tf
PA3045 280 tf
PA3184 280 tf
PA3197 280 tf
PA3596 280 tf
PA3604 280 tf
PA3879 280 tf
PA4745 280 tf
PA4853 280 tf
PA5483 280 tf
PA0780 245 tf
PA0873 245 tf
PA1309 245 tf
PA1335 245 tf
PA1359 245 tf
PA1607 245 tf
PA2020 245 tf
PA2032 245 tf
PA2885 245 tf
PA2957 245 tf
PA3220 245 tf
PA3508 245 tf
PA3594 245 tf
PA3604 245 tf
PA3711 245 tf
PA3782 245 tf
PA3830 245 tf
PA4203 245 tf
PA4764 245 tf
PA4906 245 tf
PA4984 245 tf
PA4989 245 tf
PA5253 245 tf

Warning: PA1242 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
3318 3.30e+03 gCttTTCC
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3319 3.30e+04 GAAATcCAt
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3388 4.90e-05 GaacgaGGTttCaCtGGcaGGAtC
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3389 2.90e+02 GTgCCGgCGaGgTta
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for PA1242

PA1242 is enriched for 3 functions in 3 categories.
Enrichment Table (3)
Function System
Subtilisin-like serine proteases cog/ cog
subtilase activity go/ molecular_function
proteolysis go/ biological_process
Module neighborhood information for PA1242

PA1242 has total of 62 gene neighbors in modules 245, 280
Gene neighbors (62)
Gene Common Name Description Module membership
PA0255 PA0255 hypothetical protein (NCBI) 170, 245
PA0307 PA0307 hypothetical protein (NCBI) 72, 245
PA0360 PA0360 hypothetical protein (NCBI) 170, 245
PA0584 cca tRNA nucleotidyl transferase (NCBI) 245, 306
PA0600 PA0600 probable two-component sensor (NCBI) 175, 245
PA0780 pruR proline utilization regulator (NCBI) 245, 550
PA0787 PA0787 hypothetical protein (NCBI) 245, 537
PA1111 PA1111 hypothetical protein (NCBI) 280, 322
PA1242 PA1242 hypothetical protein (NCBI) 245, 280
PA1325 PA1325 hypothetical protein (NCBI) 33, 245
PA1451 PA1451 hypothetical protein (NCBI) 97, 245
PA1469 PA1469 hypothetical protein (NCBI) 245, 337
PA1576 PA1576 probable 3-hydroxyisobutyrate dehydrogenase (NCBI) 63, 245
PA1672 PA1672 hypothetical protein (NCBI) 245, 397
PA1841 PA1841 hypothetical protein (NCBI) 181, 245
PA1921 PA1921 hypothetical protein (NCBI) 280, 450
PA1931 PA1931 probable ferredoxin (NCBI) 280, 295
PA1932 PA1932 probable hydroxylase molybdopterin-containing subunit (NCBI) 280, 537
PA1933 PA1933 probable hydroxylase large subunit (NCBI) 280, 537
PA1960 PA1960 hypothetical protein (NCBI) 245, 438
PA2032 PA2032 probable transcriptional regulator (NCBI) 192, 245
PA2108 PA2108 pyruvate decarboxylase (NCBI) 280, 521
PA2136 PA2136 hypothetical protein (NCBI) 280, 283
PA2137 PA2137 hypothetical protein (NCBI) 161, 280
PA2138 PA2138 DNA ligase (NCBI) 161, 280
PA2140 PA2140 probable metallothionein (NCBI) 161, 280
PA2141 PA2141 hypothetical protein (NCBI) 161, 280
PA2150 PA2150 hypothetical protein (NCBI) 280, 521
PA2178 PA2178 hypothetical protein (NCBI) 161, 280
PA2179 PA2179 hypothetical protein (NCBI) 161, 280
PA2181 PA2181 hypothetical protein (NCBI) 161, 280
PA2187 PA2187 hypothetical protein (NCBI) 280, 521
PA2189 PA2189 hypothetical protein (NCBI) 161, 280
PA2244 pslN hypothetical protein (NCBI) 24, 280
PA2416 treA periplasmic trehalase precursor (NCBI) 194, 280
PA2558 PA2558 probable transport protein (NCBI) 48, 245
PA2695 PA2695 hypothetical protein (NCBI) 229, 245
PA2712 PA2712 hypothetical protein (NCBI) 245, 337
PA2842 PA2842 hypothetical protein (NCBI) 245, 374
PA2860 PA2860 hypothetical protein (NCBI) 229, 245
PA3015 PA3015 hypothetical protein (NCBI) 245, 313
PA3178 PA3178 hypothetical protein (NCBI) 229, 245
PA3273 PA3273 hypothetical protein (NCBI) 280, 479
PA3274 PA3274 hypothetical protein (NCBI) 280, 479
PA3782 PA3782 probable transcriptional regulator (NCBI) 226, 245
PA3825 PA3825 hypothetical protein (NCBI) 245, 266
PA4114 PA4114 spermidine acetyltransferase (NCBI) 9, 245
PA4172 PA4172 probable nuclease (NCBI) 280, 521
PA4344 PA4344 probable hydrolase (NCBI) 280, 334
PA4374 PA4374 probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor (NCBI) 245, 313
PA4383 PA4383 hypothetical protein (NCBI) 245, 283
PA4531 PA4531 hypothetical protein (NCBI) 245, 321
PA4656 PA4656 hypothetical protein (NCBI) 243, 245
PA4716 PA4716 hypothetical protein (NCBI) 196, 245
PA4780 PA4780 hypothetical protein (NCBI) 245, 248
PA4983 PA4983 probable two-component response regulator (NCBI) 245, 469
PA4984 PA4984 probable transcriptional regulator (NCBI) 245, 507
PA5145 PA5145 hypothetical protein (NCBI) 245, 313
PA5200 ompR two-component response regulator OmpR (NCBI) 245, 253
PA5248 PA5248 hypothetical protein (NCBI) 245, 383
PA5275 cyaY frataxin-like protein (NCBI) 243, 245
PA5287 amtB ammonium transporter AmtB (NCBI) 236, 245
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for PA1242
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend