Organism : Pseudomonas aeruginosa | Module List :
PA1594

hypothetical protein (NCBI)

CircVis
Functional Annotations (1)
Function System
Uncharacterized protein, possibly involved in aromatic compounds catabolism cog/ cog
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for PA1594
(Mouseover regulator name to see its description)

PA1594 is regulated by 31 influences and regulates 0 modules.
Regulators for PA1594 (31)
Regulator Module Operator
PA0125 299 tf
PA0236 299 tf
PA0961 299 tf
PA2047 299 tf
PA2115 299 tf
PA2921 299 tf
PA3133 299 tf
PA3322 299 tf
PA3604 299 tf
PA3921 299 tf
PA4853 299 tf
PA5253 299 tf
PA5403 299 tf
PA5437 299 tf
PA0037 229 tf
PA0514 229 tf
PA0828 229 tf
PA1141 229 tf
PA1184 229 tf
PA1285 229 tf
PA1359 229 tf
PA1853 229 tf
PA2020 229 tf
PA2115 229 tf
PA2802 229 tf
PA2859 229 tf
PA3266 229 tf
PA3322 229 tf
PA3604 229 tf
PA4145 229 tf
PA4769 229 tf

Warning: PA1594 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
3286 1.50e+02 CgGgTAGAATgccCGcC.cTc
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3287 1.00e+03 agGc.gtACactGgGCg
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3426 4.10e+03 tagcCcTa.gaaAa
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3427 1.30e+01 AAggAAAa
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for PA1594

PA1594 is enriched for 1 functions in 3 categories.
Module neighborhood information for PA1594

PA1594 has total of 60 gene neighbors in modules 229, 299
Gene neighbors (60)
Gene Common Name Description Module membership
PA0236 PA0236 probable transcriptional regulator (NCBI) 299, 335
PA0419 PA0419 hypothetical protein (NCBI) 229, 247
PA0560 PA0560 hypothetical protein (NCBI) 229, 375
PA0923 dinP DNA polymerase IV (NCBI) 299, 412
PA0948 PA0948 hypothetical protein (NCBI) 214, 229
PA0951 PA0951 probable ribonuclease (NCBI) 229, 253
PA0995 ogt methylated-DNA--protein-cysteinemethyltransferase (NCBI) 30, 229
PA1026 PA1026 hypothetical protein (NCBI) 48, 299
PA1075 PA1075 hypothetical protein (NCBI) 139, 229
PA1139 PA1139 hypothetical protein (NCBI) 187, 229
PA1141 PA1141 probable transcriptional regulator (NCBI) 68, 229
PA1222 PA1222 probable membrane-bound lytic murein transglycolase A (NCBI) 62, 229
PA1285 PA1285 probable transcriptional regulator (NCBI) 229, 408
PA1398 PA1398 hypothetical protein (NCBI) 220, 229
PA1593 PA1593 hypothetical protein (NCBI) 247, 299
PA1594 PA1594 hypothetical protein (NCBI) 229, 299
PA1645 PA1645 hypothetical protein (NCBI) 229, 457
PA1686 alkA DNA-3-methyladenine glycosidase II (NCBI) 189, 229
PA1839 PA1839 hypothetical protein (NCBI) 299, 501
PA1959 bacA bacitracin resistance protein (NCBI) 299, 412
PA2039 PA2039 hypothetical protein (NCBI) 247, 299
PA2568 PA2568 hypothetical protein (NCBI) 139, 229
PA2695 PA2695 hypothetical protein (NCBI) 229, 245
PA2749 endA DNA-specific endonuclease I (NCBI) 138, 299
PA2750 PA2750 hypothetical protein (NCBI) 247, 299
PA2770 PA2770 hypothetical protein (NCBI) 139, 299
PA2773 PA2773 hypothetical protein (NCBI) 229, 445
PA2860 PA2860 hypothetical protein (NCBI) 229, 245
PA2972 PA2972 Maf-like protein (NCBI) 1, 299
PA3130 PA3130 hypothetical protein (NCBI) 229, 313
PA3131 PA3131 probable aldolase (NCBI) 178, 229
PA3178 PA3178 hypothetical protein (NCBI) 229, 245
PA3288 PA3288 hypothetical protein (NCBI) 229, 313
PA3388 PA3388 hypothetical protein (NCBI) 299, 351
PA3463 PA3463 hypothetical protein (NCBI) 72, 229
PA3573 PA3573 probable major facilitator superfamily (MFS) transporter (NCBI) 181, 299
PA3725 recJ single-stranded-DNA-specific exonuclease RecJ (NCBI) 65, 299
PA3958 PA3958 hypothetical protein (NCBI) 229, 249
PA3968 PA3968 probable pseudouridine synthase (NCBI) 86, 229
PA3990 PA3990 hypothetical protein (NCBI) 255, 299
PA4075 PA4075 hypothetical protein (NCBI) 229, 422
PA4233 PA4233 probable major facilitator superfamily (MFS) transporter (NCBI) 299, 422
PA4280 birA biotin--protein ligase (NCBI) 299, 474
PA4391 PA4391 hypothetical protein (NCBI) 48, 299
PA4445 PA4445 hypothetical protein (NCBI) 299, 422
PA4629 PA4629 hypothetical protein (NCBI) 65, 299
PA4634 PA4634 hypothetical protein (NCBI) 299, 351
PA4637 PA4637 hypothetical protein (NCBI) 139, 229
PA4718 PA4718 hypothetical protein (NCBI) 139, 229
PA4783 PA4783 hypothetical protein (NCBI) 101, 229
PA4789 PA4789 hypothetical protein (NCBI) 229, 351
PA4790 PA4790 hypothetical protein (NCBI) 229, 351
PA4801 PA4801 hypothetical protein (NCBI) 299, 490
PA5019 PA5019 hypothetical protein (NCBI) 143, 229
PA5021 PA5021 potassium/proton antiporter (RefSeq) 299, 306
PA5194 PA5194 hypothetical protein (NCBI) 247, 299
PA5228 PA5228 hypothetical protein (NCBI) 109, 229
PA5259 hemD uroporphyrinogen-III synthetase (NCBI) 229, 296
PA5437 PA5437 probable transcriptional regulator (NCBI) 299, 412
PA5485 PA5485 hypothetical protein (NCBI) 126, 229
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for PA1594
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend